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Gene : PCSK9 - ENSG00000169174 - Homo sapiens (human)

General information

Expressed in right lobe of liver and 114 other cell types or tissues.

Gene identifier

ENSG00000169174

Name

PCSK9

Description

proprotein convertase subtilisin/kexin type 9 [Source:HGNC Symbol;Acc:HGNC:20001]

Organism

Homo sapiens (human)

Synonym(s)

fh3,hchola3,narc-1

Orthologs

36 orthologs

Source data

Retrieve all processed expression values for that gene

Expression graph

80%

Expression table

80%

Reported absence of expression

80%

Orthologs

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Taxon Name	Species with orthologs	Gene(s)	Expression comparison
Homininae	3 species Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee)	3 genes ENSGGOG00000003530 PCSK9 ENSPPAG00000032319 PCSK9 ENSPTRG00000000783 PCSK9	Compare expression
Catarrhini	9 species Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Chlorocebus sabaeus (Green monkey)	9 genes ENSCATG00000039450 PCSK9 ENSMFAG00000002375 PCSK9 ENSMMUG00000005736 PCSK9 ENSMNEG00000036087 PCSK9 ENSPANG00000019345 PCSK9 ENSGGOG00000003530 PCSK9 ENSPPAG00000032319 PCSK9 ENSPTRG00000000783 PCSK9 ENSCSAG00000001316 PCSK9	Compare expression
Simiiformes	10 species Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Chlorocebus sabaeus (Green monkey)	10 genes ENSCJAG00000015682 PCSK9 ENSCATG00000039450 PCSK9 ENSMFAG00000002375 PCSK9 ENSMMUG00000005736 PCSK9 ENSMNEG00000036087 PCSK9 ENSPANG00000019345 PCSK9 ENSGGOG00000003530 PCSK9 ENSPPAG00000032319 PCSK9 ENSPTRG00000000783 PCSK9 ENSCSAG00000001316 PCSK9	Compare expression
Primates	11 species Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey)	11 genes ENSCJAG00000015682 PCSK9 ENSCATG00000039450 PCSK9 ENSMFAG00000002375 PCSK9 ENSMMUG00000005736 PCSK9 ENSMNEG00000036087 PCSK9 ENSPANG00000019345 PCSK9 ENSGGOG00000003530 PCSK9 ENSPPAG00000032319 PCSK9 ENSPTRG00000000783 PCSK9 ENSMICG00000014849 PCSK9 ENSCSAG00000001316 PCSK9	Compare expression
Euarchontoglires	15 species Mus musculus (mouse) Oryctolagus cuniculus (rabbit) Cavia porcellus (guinea pig) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Rattus norvegicus (rat)	15 genes ENSMUSG00000044254 Pcsk9 ENSOCUG00000023343 PCSK9 ENSCPOG00000015659 PCSK9 ENSCJAG00000015682 PCSK9 ENSCATG00000039450 PCSK9 ENSMFAG00000002375 PCSK9 ENSMMUG00000005736 PCSK9 ENSMNEG00000036087 PCSK9 ENSPANG00000019345 PCSK9 ENSGGOG00000003530 PCSK9 ENSPPAG00000032319 PCSK9 ENSPTRG00000000783 PCSK9 ENSMICG00000014849 PCSK9 ENSCSAG00000001316 PCSK9 ENSRNOG00000006280 Pcsk9	Compare expression
Boreoeutheria	16 species Mus musculus (mouse) Sus scrofa (pig) Oryctolagus cuniculus (rabbit) Cavia porcellus (guinea pig) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Rattus norvegicus (rat)	16 genes ENSMUSG00000044254 Pcsk9 ENSSSCG00000025020 PCSK9 ENSOCUG00000023343 PCSK9 ENSCPOG00000015659 PCSK9 ENSCJAG00000015682 PCSK9 ENSCATG00000039450 PCSK9 ENSMFAG00000002375 PCSK9 ENSMMUG00000005736 PCSK9 ENSMNEG00000036087 PCSK9 ENSPANG00000019345 PCSK9 ENSGGOG00000003530 PCSK9 ENSPPAG00000032319 PCSK9 ENSPTRG00000000783 PCSK9 ENSMICG00000014849 PCSK9 ENSCSAG00000001316 PCSK9 ENSRNOG00000006280 Pcsk9	Compare expression
Theria	17 species Mus musculus (mouse) Sus scrofa (pig) Oryctolagus cuniculus (rabbit) Cavia porcellus (guinea pig) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Rattus norvegicus (rat) Monodelphis domestica (opossum)	17 genes ENSMUSG00000044254 Pcsk9 ENSSSCG00000025020 PCSK9 ENSOCUG00000023343 PCSK9 ENSCPOG00000015659 PCSK9 ENSCJAG00000015682 PCSK9 ENSCATG00000039450 PCSK9 ENSMFAG00000002375 PCSK9 ENSMMUG00000005736 PCSK9 ENSMNEG00000036087 PCSK9 ENSPANG00000019345 PCSK9 ENSGGOG00000003530 PCSK9 ENSPPAG00000032319 PCSK9 ENSPTRG00000000783 PCSK9 ENSMICG00000014849 PCSK9 ENSCSAG00000001316 PCSK9 ENSRNOG00000006280 Pcsk9 ENSMODG00000003830 PCSK9	Compare expression
Mammalia	18 species Mus musculus (mouse) Sus scrofa (pig) Oryctolagus cuniculus (rabbit) Cavia porcellus (guinea pig) Ornithorhynchus anatinus (platypus) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Rattus norvegicus (rat) Monodelphis domestica (opossum)	18 genes ENSMUSG00000044254 Pcsk9 ENSSSCG00000025020 PCSK9 ENSOCUG00000023343 PCSK9 ENSCPOG00000015659 PCSK9 ENSOANG00000050090 PCSK9 ENSCJAG00000015682 PCSK9 ENSCATG00000039450 PCSK9 ENSMFAG00000002375 PCSK9 ENSMMUG00000005736 PCSK9 ENSMNEG00000036087 PCSK9 ENSPANG00000019345 PCSK9 ENSGGOG00000003530 PCSK9 ENSPPAG00000032319 PCSK9 ENSPTRG00000000783 PCSK9 ENSMICG00000014849 PCSK9 ENSCSAG00000001316 PCSK9 ENSRNOG00000006280 Pcsk9 ENSMODG00000003830 PCSK9	Compare expression
Amniota	21 species Mus musculus (mouse) Sus scrofa (pig) Oryctolagus cuniculus (rabbit) Cavia porcellus (guinea pig) Gallus gallus (chicken) Meleagris gallopavo (Wild turkey) Ornithorhynchus anatinus (platypus) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Rattus norvegicus (rat) Monodelphis domestica (opossum) Anolis carolinensis (green anole)	21 genes ENSMUSG00000044254 Pcsk9 ENSSSCG00000025020 PCSK9 ENSOCUG00000023343 PCSK9 ENSCPOG00000015659 PCSK9 ENSGALG00000047448 PCSK9 ENSMGAG00000011432 PCSK9 ENSOANG00000050090 PCSK9 ENSCJAG00000015682 PCSK9 ENSCATG00000039450 PCSK9 ENSMFAG00000002375 PCSK9 ENSMMUG00000005736 PCSK9 ENSMNEG00000036087 PCSK9 ENSPANG00000019345 PCSK9 ENSGGOG00000003530 PCSK9 ENSPPAG00000032319 PCSK9 ENSPTRG00000000783 PCSK9 ENSMICG00000014849 PCSK9 ENSCSAG00000001316 PCSK9 ENSRNOG00000006280 Pcsk9 ENSMODG00000003830 PCSK9 ENSACAG00000000146 PCSK9	Compare expression
Tetrapoda	23 species Mus musculus (mouse) Sus scrofa (pig) Oryctolagus cuniculus (rabbit) Cavia porcellus (guinea pig) Gallus gallus (chicken) Meleagris gallopavo (Wild turkey) Ornithorhynchus anatinus (platypus) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Rattus norvegicus (rat) Monodelphis domestica (opossum) Xenopus laevis (African clawed frog) Xenopus tropicalis (western clawed frog) Anolis carolinensis (green anole)	24 genes ENSMUSG00000044254 Pcsk9 ENSSSCG00000025020 PCSK9 ENSOCUG00000023343 PCSK9 ENSCPOG00000015659 PCSK9 ENSGALG00000047448 PCSK9 ENSMGAG00000011432 PCSK9 ENSOANG00000050090 PCSK9 ENSCJAG00000015682 PCSK9 ENSCATG00000039450 PCSK9 ENSMFAG00000002375 PCSK9 ENSMMUG00000005736 PCSK9 ENSMNEG00000036087 PCSK9 ENSPANG00000019345 PCSK9 ENSGGOG00000003530 PCSK9 ENSPPAG00000032319 PCSK9 ENSPTRG00000000783 PCSK9 ENSMICG00000014849 PCSK9 ENSCSAG00000001316 PCSK9 ENSRNOG00000006280 Pcsk9 ENSMODG00000003830 PCSK9 108715614 pcsk9.S 495509 pcsk9.L ENSXETG00000020012 pcsk9 ENSACAG00000000146 PCSK9	Compare expression
Sarcopterygii	24 species Mus musculus (mouse) Sus scrofa (pig) Oryctolagus cuniculus (rabbit) Cavia porcellus (guinea pig) Gallus gallus (chicken) Meleagris gallopavo (Wild turkey) Ornithorhynchus anatinus (platypus) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Rattus norvegicus (rat) Monodelphis domestica (opossum) Xenopus laevis (African clawed frog) Xenopus tropicalis (western clawed frog) Anolis carolinensis (green anole) Latimeria chalumnae (Coelacanth)	25 genes ENSMUSG00000044254 Pcsk9 ENSSSCG00000025020 PCSK9 ENSOCUG00000023343 PCSK9 ENSCPOG00000015659 PCSK9 ENSGALG00000047448 PCSK9 ENSMGAG00000011432 PCSK9 ENSOANG00000050090 PCSK9 ENSCJAG00000015682 PCSK9 ENSCATG00000039450 PCSK9 ENSMFAG00000002375 PCSK9 ENSMMUG00000005736 PCSK9 ENSMNEG00000036087 PCSK9 ENSPANG00000019345 PCSK9 ENSGGOG00000003530 PCSK9 ENSPPAG00000032319 PCSK9 ENSPTRG00000000783 PCSK9 ENSMICG00000014849 PCSK9 ENSCSAG00000001316 PCSK9 ENSRNOG00000006280 Pcsk9 ENSMODG00000003830 PCSK9 108715614 pcsk9.S 495509 pcsk9.L ENSXETG00000020012 pcsk9 ENSACAG00000000146 PCSK9 ENSLACG00000009719 PCSK9	Compare expression
Euteleostomi	34 species Mus musculus (mouse) Danio rerio (zebrafish) Sus scrofa (pig) Oryctolagus cuniculus (rabbit) Cavia porcellus (guinea pig) Gallus gallus (chicken) Meleagris gallopavo (Wild turkey) Ornithorhynchus anatinus (platypus) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Rattus norvegicus (rat) Monodelphis domestica (opossum) Xenopus laevis (African clawed frog) Xenopus tropicalis (western clawed frog) Anolis carolinensis (green anole) Lepisosteus oculatus (Spotted gar) Anguilla anguilla (European freshwater eel) Astyanax mexicanus (Blind cave fish) Poecilia reticulata (Guppy) Oryzias latipes (Japanese rice fish) Astatotilapia calliptera (Eastern happy) Neolamprologus brichardi (Fairy cichlid) Scophthalmus maximus (Turbot) Nothobranchius furzeri (Turquoise killifish) Latimeria chalumnae (Coelacanth)	35 genes ENSMUSG00000044254 Pcsk9 ENSDARG00000074185 pcsk9 ENSSSCG00000025020 PCSK9 ENSOCUG00000023343 PCSK9 ENSCPOG00000015659 PCSK9 ENSGALG00000047448 PCSK9 ENSMGAG00000011432 PCSK9 ENSOANG00000050090 PCSK9 ENSCJAG00000015682 PCSK9 ENSCATG00000039450 PCSK9 ENSMFAG00000002375 PCSK9 ENSMMUG00000005736 PCSK9 ENSMNEG00000036087 PCSK9 ENSPANG00000019345 PCSK9 ENSGGOG00000003530 PCSK9 ENSPPAG00000032319 PCSK9 ENSPTRG00000000783 PCSK9 ENSMICG00000014849 PCSK9 ENSCSAG00000001316 PCSK9 ENSRNOG00000006280 Pcsk9 ENSMODG00000003830 PCSK9 108715614 pcsk9.S 495509 pcsk9.L ENSXETG00000020012 pcsk9 ENSACAG00000000146 PCSK9 ENSLOCG00000008732 pcsk9 118225000 pcsk9 ENSAMXG00000013353 pcsk9 ENSPREG00000020976 pcsk9 ENSORLG00000001627 pcsk9 ENSACLG00000014003 pcsk9 ENSNBRG00000023919 ENSSMAG00000016575 pcsk9 ENSNFUG00015021230 pcsk9 ENSLACG00000009719 PCSK9	Compare expression
Chordata	35 species Mus musculus (mouse) Danio rerio (zebrafish) Sus scrofa (pig) Oryctolagus cuniculus (rabbit) Cavia porcellus (guinea pig) Gallus gallus (chicken) Meleagris gallopavo (Wild turkey) Ornithorhynchus anatinus (platypus) Callithrix jacchus (White-tufted-ear marmoset) Cercocebus atys (Sooty mangabey) Macaca fascicularis (Crab-eating macaque) Macaca mulatta (macaque) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) Gorilla gorilla (gorilla) Pan paniscus (bonobo) Pan troglodytes (chimpanzee) Microcebus murinus (Gray mouse lemur) Chlorocebus sabaeus (Green monkey) Rattus norvegicus (rat) Monodelphis domestica (opossum) Xenopus laevis (African clawed frog) Xenopus tropicalis (western clawed frog) Anolis carolinensis (green anole) Lepisosteus oculatus (Spotted gar) Anguilla anguilla (European freshwater eel) Astyanax mexicanus (Blind cave fish) Poecilia reticulata (Guppy) Oryzias latipes (Japanese rice fish) Astatotilapia calliptera (Eastern happy) Neolamprologus brichardi (Fairy cichlid) Scophthalmus maximus (Turbot) Nothobranchius furzeri (Turquoise killifish) Branchiostoma lanceolatum (Common lancelet) Latimeria chalumnae (Coelacanth)	36 genes ENSMUSG00000044254 Pcsk9 ENSDARG00000074185 pcsk9 ENSSSCG00000025020 PCSK9 ENSOCUG00000023343 PCSK9 ENSCPOG00000015659 PCSK9 ENSGALG00000047448 PCSK9 ENSMGAG00000011432 PCSK9 ENSOANG00000050090 PCSK9 ENSCJAG00000015682 PCSK9 ENSCATG00000039450 PCSK9 ENSMFAG00000002375 PCSK9 ENSMMUG00000005736 PCSK9 ENSMNEG00000036087 PCSK9 ENSPANG00000019345 PCSK9 ENSGGOG00000003530 PCSK9 ENSPPAG00000032319 PCSK9 ENSPTRG00000000783 PCSK9 ENSMICG00000014849 PCSK9 ENSCSAG00000001316 PCSK9 ENSRNOG00000006280 Pcsk9 ENSMODG00000003830 PCSK9 108715614 pcsk9.S 495509 pcsk9.L ENSXETG00000020012 pcsk9 ENSACAG00000000146 PCSK9 ENSLOCG00000008732 pcsk9 118225000 pcsk9 ENSAMXG00000013353 pcsk9 ENSPREG00000020976 pcsk9 ENSORLG00000001627 pcsk9 ENSACLG00000014003 pcsk9 ENSNBRG00000023919 ENSSMAG00000016575 pcsk9 ENSNFUG00015021230 pcsk9 BL20321 PCSK9 ENSLACG00000009719 PCSK9	Compare expression