Conservation, acquisition, and functional impact of sex-biased gene expression in mammalian tissues

Experiment ID:SRP181218
Technology:RNA-Seq
Description:Sex differences are widespread in human health and disease, which are frequently modeled in other mammalian species. However, the extent to which molecular sex differences are conserved across both tissues and species remains unclear. We conducted a 12-tissue, five-species survey of sex differences in gene expression using both publicly available (human) and newly generated (cynomolgus macaque, mouse, rat, and dog) RNA sequencing data. In each of the tissues assessed, we identified between 128 and 805 genes with conserved sex-biased expression. However, most sex bias in gene expression (~77%) - both female and male - has arisen since the last common ancestor of boroeutherian mammals, likely facilitated by reduced selective constraint. Evolutionary gains and losses of regulation by sex-biased transcription factors drove a significant fraction (~27%) of lineage-specific changes in sex bias. Our study suggests caution in the use of other species as models of human sex differences, and that similar selective pressures have driven sex-biased gene expression both within and outside the reproductive tract. Overall design: Tissue transcriptomes from 12 tissues and 4 species, 3 males and 3 females per species (before removal of outliers) were sequenced and compared for sex differences
Source:SRP181218  SRA
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Bulk RNA-Seq processed expression values in Rattus norvegicusBulk RNA-Seq processed expression values in Macaca fascicularisBulk RNA-Seq processed expression values in Mus musculusBulk RNA-Seq processed expression values in Canis lupus familiaris

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Showing 1 to 20 of 307 entries

Library ID
Identifier of the RNA-Seq library
Anat. entity ID
ID of the anatomical localization of the sample
Anat. entity name
Name of the anatomical localization of the sample
Anat. entity author annotation
Free text annotation of anatomical localization of the sample as provided by authors
Stage ID
ID of the developmental and life stage of the sample
Stage name
Name of the developmental and life stage of the sample
Stage author annotation
Free text annotation of the developmental and life stage of the sample as provided by authors
Sex
Annotation of the sex of the sample
Strain
Annotation of the strain of the sample
Time
Free text annotation of the time of sampling as provided by authors
Time unit
Unit for the time of sampling as provided by authors
Species
Physiological status
Physiological status of the organism at time of sampling
Technology
Sequencing platform
Sequenced transcript part
Possible values are: full length, all parts of the transcript are sequenced; 3': only the 3' end of the transcript is sequenced; 5': only the 5' end of the transcript is sequenced.
Fragmentation
Size of the RNA fragmentation
Run sequencing type
Paired-end or single-read run
Total read count
Total number of reads for the library.
Mapped read count
Number of reads that could be mapped to the transcriptome.
Total UMI count
Total number of individual RNA molecules (UMI) for the annotated sample. Only applicable for libraries producing UMIs.
Mapped UMI count
Number of UMIs that could be mapped to the transcriptome. Only applicable for libraries producing UMIs.
Distinct rank count
When performing a fractional ranking of the genes in the annotated sample, based on their expression level, number of distinct ranks observed, to have a value of the power for distinguishing expression levels. Used as a weight to compute a weighted mean rank accross samples for each gene and compute expression scores in Bgee.
Max rank
When performing a fractional ranking of the genes in the annotated sample, based on their expression level, maximum rank attained in the sample. Used to normalize ranks accross samples and compute expression scores in Bgee.
Link to processed expression values
See the processed expression value results for this assay
SRX5279670UBERON:0001013 adipose tissueAdiposeUBERON:0000113 post-juvenile72 monthsmaleMauritius colony (Novaprim Group)NANAMacaca fascicularisNAIlluminaIllumina HiSeq 2500FULL_LENGTH75paired3060170321927534001881921204.5Browse results
SRX5279671UBERON:0002369 adrenal glandAdrenalUBERON:0000113 post-juvenile72 monthsmaleMauritius colony (Novaprim Group)NANAMacaca fascicularisNAIlluminaIllumina HiSeq 2500FULL_LENGTH100paired171936407127167405002034722313Browse results
SRX5279672UBERON:0000473 testisTestisMmusDv:0000154 8-week-old stage (mouse)8 weeksmaleC57/BL6JNANAMus musculusNAIlluminaIllumina HiSeq 2500FULL_LENGTH75paired7112887455220956003180638264Browse results
SRX5279673UBERON:0000473 testisTestisMmusDv:0000154 8-week-old stage (mouse)8 weeksmaleC57/BL6JNANAMus musculusNAIlluminaIllumina HiSeq 2500FULL_LENGTH75paired6028304044991914003208238420.5Browse results
SRX5279674UBERON:0000473 testisTestisMmusDv:0000154 8-week-old stage (mouse)8 weeksmaleC57/BL6JNANAMus musculusNAIlluminaIllumina HiSeq 2500FULL_LENGTH75paired8094798557492532003344839090.5Browse results
SRX5279675UBERON:0001013 adipose tissueAdiposeMmusDv:0000154 8-week-old stage (mouse)8 weeksmaleC57/BL6JNANAMus musculusNAIlluminaIllumina HiSeq 2500FULL_LENGTH75paired3784176233734502002357532153Browse results
SRX5279676UBERON:0001013 adipose tissueAdiposeMmusDv:0000154 8-week-old stage (mouse)8 weeksmaleC57/BL6JNANAMus musculusNAIlluminaIllumina HiSeq 2500FULL_LENGTH75paired8024554667307626002369432291.5Browse results
SRX5279677UBERON:0002369 adrenal glandAdrenalUBERON:0034919 juvenile stage9 weeksmaleBrown NorwayNANARattus norvegicusNAIlluminaIllumina HiSeq 2500FULL_LENGTH75paired5807549144092820001943222795.5Browse results
SRX5279678UBERON:0000955 brainBrainUBERON:0034919 juvenile stage9 weeksmaleBrown NorwayNANARattus norvegicusNAIlluminaIllumina HiSeq 2500FULL_LENGTH75paired4201072631160498001998723201.5Browse results
SRX5279679UBERON:0001155 colonColonUBERON:0034919 juvenile stage9 weeksmaleBrown NorwayNANARattus norvegicusNAIlluminaIllumina HiSeq 2500FULL_LENGTH75paired3854544528406560001980622996.5Browse results
SRX5279680UBERON:0001155 colonHeartUBERON:0034919 juvenile stage9 weeksmaleBrown NorwayNANARattus norvegicusNAIlluminaIllumina HiSeq 2500FULL_LENGTH75paired4410077335221299001860722302Browse results
SRX5279681UBERON:0002107 liverLiverUBERON:0034919 juvenile stage9 weeksmaleBrown NorwayNANARattus norvegicusNAIlluminaIllumina HiSeq 2500FULL_LENGTH100paired11419191096203197001845522279.5Browse results
SRX5279682UBERON:0002048 lungLungUBERON:0034919 juvenile stage9 weeksmaleBrown NorwayNANARattus norvegicusNAIlluminaIllumina HiSeq 2500FULL_LENGTH75paired6690793348726179002067423690.5Browse results
SRX5279683UBERON:0002385 muscle tissueMuscleUBERON:0034919 juvenile stage9 weeksmaleBrown NorwayNANARattus norvegicusNAIlluminaIllumina HiSeq 2500FULL_LENGTH75paired5538471244941340001722921439.5Browse results
SRX5279684UBERON:0000014 zone of skinSkinUBERON:0034919 juvenile stage9 weeksmaleBrown NorwayNANARattus norvegicusNAIlluminaIllumina HiSeq 2500FULL_LENGTH75paired3973084931634185001950722868.5Browse results
SRX5279685UBERON:0002106 spleenSpleenUBERON:0034919 juvenile stage9 weeksmaleBrown NorwayNANARattus norvegicusNAIlluminaIllumina HiSeq 2500FULL_LENGTH100paired209594963155858182002099723643.5Browse results
SRX5279686UBERON:0002046 thyroid glandThyroidUBERON:0034919 juvenile stage9 weeksmaleBrown NorwayNANARattus norvegicusNAIlluminaIllumina HiSeq 2500FULL_LENGTH75paired3649675329731971001877822320Browse results
SRX5279687UBERON:0001155 colonColonUBERON:0034919 juvenile stage9 weeksfemaleBrown NorwayNANARattus norvegicusNAIlluminaIllumina HiSeq 2500FULL_LENGTH100paired199500922150632288002075423637Browse results
SRX5279688UBERON:0002369 adrenal glandAdrenalUBERON:0034919 juvenile stage9 weeksmaleBrown NorwayNANARattus norvegicusNAIlluminaIllumina HiSeq 2500FULL_LENGTH75paired8346688863950337001963323036.5Browse results
SRX5279689UBERON:0000955 brainBrainUBERON:0034919 juvenile stage9 weeksmaleBrown NorwayNANARattus norvegicusNAIlluminaIllumina HiSeq 2500FULL_LENGTH100paired179508637128959686002145824143.5Browse results

Showing 1 to 20 of 307 entries